DIABETES: A TRANSCULTURAL HISTORY OF A DISEASE CONCEPT IN THE LATE QING AND REPUBLICAN CHINA



NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells

Abstract The P53-destabilizing TBC1D15-NOTCH protein interaction promotes self-renewal of tumor-initiating stem-like cells (TICs); however, Bamboo the mechanisms governing the regulation of this pathway have not been fully elucidated.Here, we show that TBC1D15 stabilizes NOTCH and c-JUN through blockade of E3 ligase and CDK8 recruitment to phosphod

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